The National Blues Museum is a 501(c)(3) non-profit museum in St. Louis, Missouri, United States, dedicated to exploring the musical history and impact of the blues. It exists as an entertainment and educational resource focusing on blues music. The Museum offers a rotating collection of exhibits, live performances in the Lumiere Place Legends room, and is available for private events.

The museum opened in 2016. Surly King, the daughter of B.B. King, spoke at the museum opening. The museum cost $14 million to create in a renovated historic building in downtown St. Louis. Original branding, graphic design and website were provided by the agency, Project 13.

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